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By incorporating a cycling protocol, researchers aim to provide a "washout" period, allowing receptors to potentially return to their baseline sensitivity and number

In addition, a series of new agents are in clinical development, including the AR antagonists ARN-509 44 and EPI-001 that directly target the AR, as well as orteronel (TAK-700) 45,46 and galeterone (TOK-001) 47 that indirectly target the AR

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1, 25-DihydroxyVitamin D3 attenuates IL-1 secretion by suppressing NLRP1 inflammasome activation by upregulating the NRF2-HO-1 pathway in epidermal keratinocytes