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If you switch from a compounded semaglutide with B12 to a formulation without it (or to brand-name Wegovy, which does not contain B12), you need to add B12 supplementation separately

This is particularly relevant during periods of caloric deficit or increased physical activity, where the demand for energy from fat sources is higher

Rico-BarrioIPeascoSPuenteNRamosAFontaineCRegueroLet alCognitive and neurobehavioral benefits of an enriched environment on young adult mice after chronic ethanol consumption during adolescence

For athletes and bodybuilders, this effect may support gradual improvements in muscle mass over time