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Individuals with kidney failure requiring hemodialysis lose thiamin at an increased rate and are at risk for thiamin deficiency (32)

doi:10.1038/s41598-019-49364-x 182

We have a full summary of all the major pre-clinical studies and trials below, but as Reta is in Phase III, it's clear that: It showed significant benefit and low safety risk during pre-clinical trials to justify clinical trials