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Given the limited regenerative capacity of neurons, sustained disruption of proteostasis progressively overwhelms cellular quality control systems, leading to synaptic dysfunction, neurodegeneration and irreversible cognitive or motor decline

For instance, rapid weight loss can lead to fluctuations in estrogen levels, gut and vaginal flora, or pelvic muscle tone, which may explain symptoms like dryness, discharge changes, or infections

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This can lead to small intestinal bacterial overgrowth (SIBO), altered fermentation patterns, and changes in metabolite production that affect everything from mood to immune function