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Available data on pediatric populations show controversial results, ranging from the absence of relevant changes in anti-seizure drugs' blood concentration (15) to subtle changes in topiramate, levetiracetam, phenobarbital, and carbamazepine and possibly significant changes in valproate concentration under the influence of KDT (16)

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In 2025 was published randomized, sham-controlled trial (mPNS + conventional medical management [CMM] versus sham + CMM) reported superior pain relief