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Increasing concentrations of HQ in the presence of L-tyrosine, resulted in an increase in the K m value while the V max remained constant, an indication of a competitive inhibition mode on the monophenolase activity, with a K I of 40 M and apparent K m and V max values of 0.07 mM and 9.0 mole min 1 mg 1 , respectively (Fig

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Therefore, under healthy conditions, Nrf2 serves a protective function against tumourigenesis and tumour progression by counteracting ROS-induced toxicity and genotoxic stress