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Endocrinology, 139, 31273132

L., Bailey D

As depicted in the graphic below, we have evidence in rodents and nonhuman primates that: a) ER-100 enables expression of OSK in retinal ganglion cells (RGCs), which are the cells damaged in optic neuropathies b) the epigenetic profile as measured by the DNA methylation state of genes changes with damage, but is restored with ER-100 treatment c) ER-100 improves: Investigational new drug (IND)-enabling studies for biodistribution and toxicology were successfully completed and supported the advancement of ER-100 into human clinical trials