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Second, polyphenols can directly interact with metabolic signalling pathways including AMPK (a cellular energy sensor) and NF-kB (a master inflammatory regulator)

65,78,79,80,81,82,83,84,85,86 Thus, at present, non-proliferative and proliferative astrocyte reactivity represent two broad categories that can be readily differentiated and are associated with diverse molecular and functional differences