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One of the concepts emerging from these observations is the role of non-rhythmic tonic signals as circadian tuners (or tongeber German for sound giver in reference to the term zeitgeber (time giver) describing a phasic modulator of circadian rhythms)

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Permanent opening of the mPTP results in mitochondrial depolarization, inhibition of respiration, cessation of ATP synthesis, mobilization of cytochrome C, and apoptosis 43