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A comparative study of obese and lean rats found that lean rats showed greater drops in estrogen and vitamin D and higher urinary calcium excretion after weight loss, suggesting increased sensitivity to calcium disturbances

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Dehydration is a likely contributor, especially during the first few months of treatment

The transformation in the philosophy of current drug designing from one drug-one target to multiple targets of a single drug incorporates polypharmacological analysis that intends to discover the unknown targets for the existing drugs (Yildirim et al